An Editorial Expression of Concern has been published regarding the article "A melanocyte lineage program confers resistance to MAP kinase pathway inhibition" due to raised issues over potential duplication in Extended Data Fig. 4b, impacting specific cell lines. While the editors confirm this does not affect the overall results or conclusions, the original data is no longer available for verification. Notably, only some authors have engaged with the publisher about these concerns, while there is a disagreement from one author regarding the expression of concern.
The Editorial Expression of Concern highlights the raised issues regarding potential duplication in Extended Data Fig. 4b, impacting A375 and WM266.4 cells but not the main conclusions.
Despite the concerns outlined, the impact on results and conclusions of the study remains negligible, as stated by the editors of Nature.
The lack of availability of the original raw data complicates the resolution of these concerns and is acknowledged by the Editorial on behalf of the publisher.
In contrast to the consensus from the editorial team, author Levi A. Garraway has publicly expressed disagreement with the concerns raised in this expression.
#editorial-expression-of-concern #map-kinase-pathway #research-integrity #data-duplication #melanocyte-lineage-program
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