Recent research led by Dr. Bin Zhang focuses on enhancing immune responses in cancer treatment. The first study demonstrated how tumors evade immune defenses via mechanisms involving co-stimulatory receptors like 4-1BB. By manipulating metabolic pathways and inhibiting A2BR receptors, the researchers observed increased T-cell survival and reduced exhaustion. This approach could help refine existing therapies, leading to more effective and lasting cancer treatments by maximizing T-cell activity and preventing immune fatigue.
In cancer, activated T-cells upregulate co-stimulatory receptors like 4-1BB which can be targeted to enhance T-cell activity and combat tumor evasion.
The deletion of the A2BR receptor stabilizes metabolic molecules GSH and GPX4, reducing T-cell exhaustion and promoting better immune responses in cancer.
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