"We had some opportunities, just didn't capitalize on them," interim manager Grady Sizemore said. "We just came up short."
Wagaman began the 13th on second as the automatic runner and moved to third on a flyout to right. Adams hit a grounder that deflected off third baseman Miguel Vargas' glove, and Wagaman scored easily to end the marathon.
The Sox went back ahead in the 11th on Andrew Benintendi's two-out RBI single. But the Angels responded with an RBI single by Wagaman.
The Sox stranded the bases loaded in the 13th, with Yoán Moncada striking out in his first major-league at-bat since April 9.
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