David Pastrnak and Danton Heinen each had a goal and an assist in the first period.
Frederik Andersen, in his 100th game as a Hurricane, fell to 11-2-0 this season.
Marchand took Morgan Geekie's pass to go in on Andersen, who initially blocked the shot, but the puck got under his pads and into the net.
Guentzel has 25 goals this season, including three in 12 games since joining the Hurricanes in a trade from Pittsburgh.
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