"Therefore, clinicians need help to identify those who will go on to have psychotic symptoms using not only subclinical signs, such as changes in thinking, behaviour and emotions, but also some biological markers," said Koike.
At most only 30 per cent of clinical high-risk individuals later have overt psychotic symptoms, while the remaining 70 per cent do not," said associate professor Shinsuke Koike from the University of Tokyo.
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