1985: Disentangling tau pathology
Briefly

The research finally illuminates the longstanding mystery of neurofibrillary tangles, which have been linked to Alzheimer's disease for decades but whose core composition remained unclear for nearly 80 years.
The identification of protein tau as the fundamental building block of neurofibrillary tangles opens up new avenues for research into Alzheimer's and related neurodegenerative conditions.
For almost 80 years, neurofibrillary tangles were recognized in Alzheimer's patients' brains, but only recently has the pivotal role of tau protein been elucidated.
This breakthrough could be instrumental in the development of potential therapies targeting tau, aiming to mitigate the progression of Alzheimer's disease in affected individuals.
Read at Nature
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