"In a randomized clinical trial involving 958 adults aged 60 or older, researchers found that taking a multivitamin-multimineral supplement for two years modestly slowed two molecular signals for aging in the body known as epigenetic clocks. Chemical changes on DNA called DNA methylation in specific parts of the genome can help estimate a person's biological age."
"In the people who took the supplement, the clocks' rate of increase slowed by around 1.5 to two months per year compared with the clocks of those who took a placebo. The findings were published Monday in Nature Medicine."
"While the researchers saw an effect with two epigenetic clocks called PCPhenoAge and PCGrimAge, three other epigenetic clocks included in the study showed no statistically significant change to their speed. The multivitamin produced small favorable changes in two epigenetic aging markers, but not across all the clocks that were measured."
Multivitamins are widely used dietary supplements in the U.S., though their health benefits remain scientifically unclear and they lack FDA approval. A randomized clinical trial with 958 adults aged 60 or older examined whether daily multivitamin-multimineral supplements affect biological aging. Researchers measured epigenetic clocks—molecular signals based on DNA methylation patterns that estimate biological age. Participants taking the supplement for two years showed a modest slowing of two epigenetic clocks (PCPhenoAge and PCGrimAge) by approximately 1.5 to two months per year compared to placebo. However, three other epigenetic clocks measured showed no statistically significant changes. Experts emphasize caution, noting the inconsistent results across different aging markers suggest the findings are preliminary and require further investigation.
Read at www.scientificamerican.com
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