Hyperoside (Hyp) shows potential in protecting the heart from myocardial infarction through JAK2/STAT3 signaling pathway modulation, based on mouse model and cell culture findings.
In vivo experiments involved different Hyp concentrations and JAK2/STAT3 inhibitor; outcomes measured via ECG, echocardiography, histopathological changes, and protein expression. In vitro, Hyp demonstrated protective effects in OGD-induced myocardial ischemia in rat cardiomyocytes.
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