Chronic pain affects 20% of US adults and 8 million Canadians, impacting mood, movement, and overall quality of life. While the effectiveness of medical cannabis (MC) and cannabidiol (CBD) varies, studies suggest cannabinoids can significantly reduce pain severity. A systematic review indicated a reduction of pain by 42-66% with CBD alone or in combination with THC. Additionally, different formulations show varying success rates across conditions. Understanding how cannabinoids work with the body's endocannabinoid system is crucial in managing chronic pain effectively, as they modify pain signaling and inflammation.
An estimated 20% of US adults experience chronic pain, which can significantly impair mood and physical functioning, leading to further complications.
Research indicates cannabinoids may reduce pain severity by 30-50% compared to placebo, showing promise particularly for neuropathic and inflammatory conditions.
Combined THC:CBD formulations, such as nabiximols, often demonstrate superior pain relief compared to single cannabinoids, with CBD reducing THC’s psychoactive effects.
Cannabinoids interact with the body’s endocannabinoid system, modulating pain signaling and inflammation, which plays a crucial role in managing chronic pain.
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