Gianluca Mancini's first-half header gave Roma a 1-0 lead against Milan in the Europa League quarter-final tie.
Roma edges victory at San Siro, setting up a chance to reach the semi-final against West Ham or Bayer Leverkusen.
Mancini's impactful performance follows his recent winning goal against Lazio. Milan's efforts were denied by Roma's defense and goalkeeper.
Both teams had opportunities in the first half, with Roma's goalkeeper Svilar saving shots from Milan's Reijnders and Leao. Pellegrini and Cristante missed chances for Roma.
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