To characterize CREs and TFs for neocortical ExNs, we used Arpp21-Gfp or Fezf2-Gfp transgenic mice and enriched GFP-expressing neocortical upper layer (L2-4) intratelencephalic (IT) neurons or deep layer (L5-6) predominantly extratelencephalic (ET) neurons, respectively, from neonatal mice (postnatal day (PD) 0), an age at which neocortical ExN identity and connectivity are established.
We found that a simple, guideline-based exercise program can make the brain look measurably younger over just 12 months. Many people worry about how to protect their brain health as they age. Studies like this offer hopeful guidance grounded in everyday habits. These absolute changes were modest, but even a one-year shift in brain age could matter over the course of decades.
I received an email recently that claims Wal-Mart senior management has been calling mandatory meetings for the company's employees in which the employees are told they "cannot" vote for the Obama-Biden ticket "or any other employee-friendly, union-friendly candidates for political office". It's not an urban legend, according to the sources I checked. This makes me so angry I just boil. When it comes to the Constitution, I am a rabid supporter.
Young, two-month-old lab mice housed with older, 18-month-old mice showed really impaired cognition. Researchers exposed young mice raised in a sterile, microbe-free environment to gut bacteria from old mice, causing the younger animals to perform worse on cognitive tests, as if they had prematurely aged, just like the cohoused mice.
A groundbreaking study found that adults who sit for 10 or more hours daily face a significantly higher risk of dementia compared to those who sit less. The research, which tracked over 50,000 adults using wearable devices, revealed that the risk increases dramatically after crossing that 10-hour threshold.
Anyone living with schizophrenia understands the true limitations of current treatment options. Antipsychotics remain the single leading treatment for the disorder, and they are riddled with undesirable side effects. Weight gain, tardive dyskinesia, and excessive drowsiness are a few. Much research is devoted to expanding the range of medication options, and few academics have pursued other avenues. However, there is a possibility that treatment for schizophrenia can be approached through cellular methods if long-term research validates early signs of hope.
Most people will forget a name, misplace their phone, or lose track of a conversation at some point. Usually, those moments pass without much thought. But for many adults, especially as they age, small lapses can trigger a much deeper fear: Is this the beginning of cognitive decline? As a neurologist, I hear this concern often. And as a researcher, I have learned something important: Worry about cognition and cognitive disease are not the same thing.
There are lots of reasons why relationships fall apart; all kinds of incompatibilities can doom romance. Some are trivial, but occasionally there might be something more profound at the root of an estrangement. Recently, the concept of the "frontal lobe breakup" appeared in popular culture. The idea is that the final stage of development in the executive regions of the brain-the frontal lobes-changes someone's perspective about their relationship. The onset of advanced cognitive skills in one partner creates a gap in maturity too big to bridge.
Neuroscientists have a name for the brain network that fires up when you're not focused on an external task: the default mode network, or DMN. It's the constellation of regions - the medial prefrontal cortex, posterior cingulate cortex, and angular gyrus among them - that hums to life when you daydream, reflect on yourself, or think about other people's mental states.
I am a worrier, and have been for most of my life. At some point, someone dear and smart teased me that I worry about the wrong things. The things that hit me, she noted, were never the things I worried about. For a while that left me feeling like an incompetent worrier-until my research caught up. I realized that the things I worry about often don't end up hurting me precisely because worrying helps me diffuse them ahead of time.
There was a group of neurons that predicted the wrong answer, yet they kept getting stronger as the model learned. So we went back to the original macaque data, and the same signal was there, hiding in plain sight. It wasn't a quirk of the model - the monkeys' brains were doing it too. Even as their performance improved, both the real and simulated brains maintained a reserve of neurons that continued to predict the incorrect answer.
Tumours lure and then hijack nearby sensory neurons to boost their own growth. The cancer cells use these neurons to send a signal to the brain that subdues the activity of immune cells around the tumour, which allows it to grow unchecked. When researchers deactivated these neurons in mice with lung cancer, they saw "a huge, dramatic reduction" in tumour growth - more than 50% - says cancer immunologist and study co-author Chengcheng Jin.
It might come as a surprise to learn that the brain responds to training in much the same way as our muscles, even though most of us never think about it that way. Clear thinking, focus, creativity, and good judgment are built through challenge, when the brain is asked to stretch beyond routine rather than run on autopilot. That slight mental discomfort is often the sign that the brain is actually being trained, a lot like that good workout burn in your muscles.
Haavik was surprised to hear this because the scientific data do not suggest an unequivocal link between low levels of the neurotransmitter dopamine and ADHD. But the idea that low dopamine is a direct cause of ADHD is a common misconception, one that's amplified on social media and even in popular books about the condition. The reality, Haavik and other researchers say, is that the causes of ADHD are more diverse and nuanced than a simple deficit in one chemical cue in the brain.
