"In 2022, more than 80,000 people died of an opioid overdose in the United States. To reduce this toll, we need to abandon analgesic drugs that act through the μ-opioid receptor and identify painkillers that cannot be so easily abused."
"The first was the assumption that the severity of pain is the only important factor to consider when selecting a suitable treatment. The second was the presumption that μ-opioid receptor agonists would be effective for all types of severe acute or chronic pain."
"After almost four decades, the WHO ladder remains widely used by clinicians - even though we now appreciate that opioids are highly dangerous. Scientists also recognize that there are several distinct types of pain, each driven by different mechanisms and requiring specific distinct interventions."
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