#tumorigenesis

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#colorectal-cancer

Polyclonality overcomes fitness barriers in Apc-driven tumorigenesis - Nature

Colorectal cancer initiation involves the competition between APC-deficient and wild-type intestinal stem cells, driven by neighborhood suppression and 'supercompetitor' behavior.

Crypt density and recruited enhancers underlie intestinal tumour initiation

Adenomas may form from Apc mutations in intestinal stem cells, but spatial distribution of mutant crypts significantly influences their development.

Polyclonality overcomes fitness barriers in Apc-driven tumorigenesis - Nature

Colorectal cancer initiation involves the competition between APC-deficient and wild-type intestinal stem cells, driven by neighborhood suppression and 'supercompetitor' behavior.

Crypt density and recruited enhancers underlie intestinal tumour initiation

Adenomas may form from Apc mutations in intestinal stem cells, but spatial distribution of mutant crypts significantly influences their development.
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