Molecular basis of oocyte cytoplasmic lattice assembly
Cryo-EM reveals the cytoplasmic lattice in mammalian oocytes comprises repeating U-shaped basket and adapter ring units with 14 protein subunits, essential for oocyte maturation and embryonic development.
Genetically encoded assembly recorder temporally resolves cellular history
GEMINI is an intracellular recording platform using designed protein assemblies to capture cellular activity history with hour-level temporal precision through fluorescent tree-ring patterns.
Regulatory grammar in human promoters uncovered by MPRA-based deep learning - Nature
Massively parallel reporter assays provide cell-type-specific causal training data enabling more direct inference of DNA sequence effects on promoter activity than epigenomic maps.
Atlas-guided discovery of transcription factors for T cell programming - Nature
Transcription factors determine CD8+ T cell states; identifying TFs that promote tissue-resident memory versus terminal exhaustion enables engineering of more effective adoptive T cell therapies.
New Underlying Mechanisms May Support Proper Transcriptional Regulation and Improve - News Center
New mechanisms controlling transcription initiation and elongation involving BET family proteins were identified, revealing pathways that could enable improved targeted therapies for diseases including cancer.
Scalable and multiplexed recorders of gene regulation dynamics across weeks
CytoTape enables multiplexed, genetically encoded, spatiotemporally scalable recording of gene regulation dynamics in single cells for up to three weeks with minute-scale resolution.
Author Correction: Cotranslational assembly of protein complexes in eukaryotes revealed by ribosome profiling
Extended Data Fig. 4d duplicated Fig. 2a and strains were partially misannotated; corrected figures are provided and do not change study results or conclusions.
Understanding the Link Between Nucleotide Metabolism and Chromatin Assembly - News Center
PRPS enzymes coordinate nucleotide synthesis and early histone maturation, synchronizing DNA replication and chromatin assembly through dual metabolic and regulatory roles.
A 45-base RNA ribozyme can self-replicate, supporting RNA-based origin-of-life scenarios where RNA carried both genetic information and catalytic functions.