#post-covid-cognitive-impairment

#post-covid-cognitive-impairment

We've always said that SuperAgers show that the aging brain can be biologically active, adaptable, flexible, but we didn't know why. This is biological proof that their brains are more plastic, and a real discovery that shows that neurogenesis of young neurons in the hippocampus may be a contributing factor.

Rumination activates the default mode network (DMN) - the brain's self-referential processing system. This is the neural circuitry that fires when you're thinking about yourself in relation to others: your identity, your social standing, your mistakes. It's the brain asking, over and over, What does this say about me?

When I asked neurologists about their top behaviors for brain health, they all stressed the importance of physical activity. Exercise is top, No. 1, when we're thinking about the biggest bang for your buck, said Dr. Gregg Day, a neurologist at the Mayo Clinic. Numerous studies have shown that people who exercise regularly tend to perform better on attention, memory and executive functioning tests. There can be a small cognitive boost immediately after a workout, and the effects are sustained if people exercise consistently.

It might come as a surprise to learn that the brain responds to training in much the same way as our muscles, even though most of us never think about it that way. Clear thinking, focus, creativity, and good judgment are built through challenge, when the brain is asked to stretch beyond routine rather than run on autopilot. That slight mental discomfort is often the sign that the brain is actually being trained, a lot like that good workout burn in your muscles.

A groundbreaking study found that adults who sit for 10 or more hours daily face a significantly higher risk of dementia compared to those who sit less. The research, which tracked over 50,000 adults using wearable devices, revealed that the risk increases dramatically after crossing that 10-hour threshold.

Betley and his colleagues were curious about what happens in the brain as people get stronger through exercise. They decided to focus on the ventromedial hypothalamus, a brain region that regulates appetite and blood sugar. The team then zeroed in on a group of neurons in that region that produce a protein called steroidogenic factor 1 (SF1), which is known to play a part in regulating metabolism. A previous study found that the deletion of the gene that codes for SF1 impairs endurance in mice.

Decades of research show that people who have more years of education, more cognitively demanding jobs or more mentally stimulating hobbies all tend to have a reduced risk of cognitive impairment as they get older. Experts think this is partly thanks to cognitive reserve: Basically, the more brain power you've built up over the years, the more you can stand to lose before you experience impairment.

If you're going to prioritize one thing for your brain health, make it this: regular aerobic exercise. Multiple large-scale studies show that aerobic exercise doesn't just keep your heart healthy-it directly impacts your brain structure. One year of aerobic exercise in older adults led to significantly larger hippocampal volumes and better spatial memory. Other trials documented that exercise actually slows age-related gray matter volume loss.

Think of your creativity like a high-performance garden: If you focus only on the visible harvest (outputs) and never allow the soil to lie fallow (liminal space) or the bees to roam freely (play), the ground eventually becomes depleted. Boredom is the signal that the soil needs replenishing, ensuring that your next season of work is a flourish rather than a struggle.

Almost all Americans are familiar with posttraumatic stress disorder ( PTSD) and its long-term, sometimes devastating effects on people's lives-crippling anxiety, depression, disturbing flashbacks, sleep problems, irritability, concentration difficulties, and much, much more. About 70 percent of U.S. adults have experienced at least one major life trauma. The fact that so many of us experience trauma makes it easier to empathize with the 10 or so percent of people who go on to develop PTSD.

Somewhere along the way, I started wearing burnout like a badge of honour. In weekly lab check-ins, I make sure to mention I was in the lab over the weekend - slipping in a quiet signal that I was going above and beyond. I've made sure to send e-mails early in the morning or late at night to demonstrate I was working long hours.