#memory-consolidation

#memory-consolidation

The molecular mechanisms that enable memories to persist over long timescales from days to weeks and months are still poorly understood1. Here, to develop insights into this process, we created a behavioural task in which mice formed multiple memories but only consolidated some, while forgetting others, over the span of weeks. We then monitored circuit-specific molecular programs that diverged between consolidated and forgotten memories. We identified multiple distinct waves of transcription, that is, cellular macrostates, in the thalamocortical circuit that defined memory persistence.

Astrocytes - brain cells once thought of as supporting players to neurons - have a principal role in stabilizing memories for long-term recall. In mice, researchers found that Fos, a gene associated with cell activity, was highly expressed in the astrocytes of mice that re-entered cages they'd been conditioned to associate with fear. The team also found that highly-active astrocytes produce more receptors that respond to the neurotransmitter noradrenaline, which allows them to communicate with neurons.