Polyclonality overcomes fitness barriers in Apc-driven tumorigenesis - NatureColorectal cancer initiation involves the competition between APC-deficient and wild-type intestinal stem cells, driven by neighborhood suppression and 'supercompetitor' behavior.
Crypt density and recruited enhancers underlie intestinal tumour initiationAdenomas may form from Apc mutations in intestinal stem cells, but spatial distribution of mutant crypts significantly influences their development.
Polyclonality overcomes fitness barriers in Apc-driven tumorigenesis - NatureColorectal cancer initiation involves the competition between APC-deficient and wild-type intestinal stem cells, driven by neighborhood suppression and 'supercompetitor' behavior.
Crypt density and recruited enhancers underlie intestinal tumour initiationAdenomas may form from Apc mutations in intestinal stem cells, but spatial distribution of mutant crypts significantly influences their development.
Short-term post-fast refeeding enhances intestinal stemness via polyamines - NaturePost-fast refeeding increases intestinal stem cell proliferation but also elevates tumor risk, emphasizing the need for careful diet strategy considerations.