#gavi-vaccine-alliance

#gavi-vaccine-alliance

On that sunny March morning, in a small health center in Lobamba, a rural area of Eswatini, this 32-year-old sex worker has just become one of the first people in the world to receive lenacapavir, a drug that, administered twice a year, offers nearly 100% protection against HIV.

I am particularly worried about the immunisation programme. If there is a disruption, the success we have achieved in immunisation will be jeopardised.

Kelly Chibale describes the drug discovery process as a fairy-tale quest, stating, 'It doesn't mean that there aren't surprises or miracles. They do happen, but you have to kiss many frogs before you meet the prince.' This metaphor illustrates the challenges and unpredictability in finding effective medicines.

The U.S. is no longer part of the World Health Organization. After the Trump administration declared its intention to pull the country out of the global public health agency one year ago, on Thursday it formally followed through, ending its commitment to the organization after 78 years. Withdrawing the U.S. from the WHO was one of Trump's day one priorities. Now, after the required one year notice period, the deed is done.

GOARN, which includes more than 310 national public health agencies, United Nations agencies, academic institutions, and nongovernmental groups, helps identify and manage infectious disease outbreaks worldwide. Since it was established in 2000, GOARN says it has helped manage more than 175 global health emergencies across 114 countries.

Risks of outbreaks with pandemic potential rise with increasing land-use change, biodiversity loss and climate change. The Pandemic Agreement adopted by the World Health Assembly in 2025 marks a historic shift that establishes the One Health approach as a legally binding obligation for pandemic prevention.

There is little doubt that this is what African countries need if they are serious about universal health coverage - ensuring that every member of their populations has access to this fundamental human right. But such an approach has never been implemented in Africa. Some of the reasons for this are outlined in a report on health financing by the Africa Centres for Disease Control and Prevention (Africa CDC), the continent's public-health agency based in Addis Ababa, published last week (see go.nature.com/3o9wxfc).

Each day, they pore over reams of data about how the virus is evolving worldwide, how well last year's shot performed, and which strains might be easiest to mass produce for a vaccine. The meeting, convened by the World Health Organization twice a year, is a critical moment for the WHO's Global Influenza Surveillance and Response System.

Aid cuts could lead to more than 22 million avoidable deaths by 2030, including 5.4 million children under five, according to the most comprehensive modelling to date. In the past two decades there have been dramatic falls in the number of young children dying from infectious diseases, driven by aid directed to the developing world, researchers wrote in the Lancet Global Health. But that progress was at risk of reversal because of abrupt budget cuts by donor countries, including the US and the UK.

From reproductive rights to climate change to Big Tech, The Independent is on the ground when the story is developing. Whether it's investigating the financials of Elon Musk's pro-Trump PAC or producing our latest documentary, 'The A Word', which shines a light on the American women fighting for reproductive rights, we know how important it is to parse out the facts from the messaging.