#epigenomics

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#paediatric-cancers #fusion-oncoproteins #ependymoma #tumour-development #promoters #deep-learning #mpras
Medicine
fromNature
1 week ago

Dominant clones leverage developmental epigenomic states to drive ependymoma - Nature

Paediatric cancers often involve fusion oncoproteins and aberrant epigenomes, with EPN being a key model for understanding their transformation mechanisms.
OMG science
fromNature
1 month ago

Regulatory grammar in human promoters uncovered by MPRA-based deep learning - Nature

Massively parallel reporter assays provide cell-type-specific causal training data enabling more direct inference of DNA sequence effects on promoter activity than epigenomic maps.
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