Revealed: Why the fatal Huntington's gene takes so long to cause harmLate onset of Huntington's disease symptoms is due to accumulated genetic errors in neurons over time, particularly affecting DNA-repair mechanisms.
Prolonged persistence of mutagenic DNA lesions in somatic cells - NatureSome DNA lesions can persist unrepaired through multiple cell cycles, generating unique mutations.High-resolution phylogenetic trees can help track DNA lesions and their mutations across somatic cell divisions.