Tipoff from Madison Square Garden in New York is set for noon ET. Creighton leads the all-time series 19-14, but St. John's has won three straight, including 90-73 on Jan. 10. St. John's is a 12.5-point favorite in the latest Creighton vs. St. John's odds from DraftKings Sportsbook, while the over/under for total points scored is 153.5. Before making any Creighton vs. St. John's picks, check out the men's college basketball predictions and betting advice from the SportsLine Projection Model.