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#g-protein-coupled-receptors #cryo-electron-microscopy #g-protein-dynamics #ntsr1-signaling
Science
fromNature
1 month ago

The dynamic basis of G-protein recognition and activation by a GPCR - Nature

NTSR1 receptor dynamically accommodates different G-protein subtypes through intracellular rearrangements, with GDP/GTP binding triggering G-protein dissociation through stepwise remodeling of switch regions.
Science
fromNature
1 month ago

DICER cleavage fidelity is governed by 5-end binding pockets - Nature

DICER is a conserved RNase III enzyme that processes precursor microRNAs and double-stranded RNAs into small regulatory RNAs through precise 5' and 3' end counting mechanisms.
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