Uncovering Regulatory Mechanisms of T-cells in Chronic Inflammation - News Center
Lag3 expression in regulatory T-cells is critical for preventing autoimmune inflammation and may be a target for therapies in inflammatory conditions and cancer.
Transferrin receptor targeting chimeras for membrane protein degradation - Nature
TransTACs represent a promising strategy for targeted cancer therapy through the degradation of membrane proteins.
Intercellular Mechanisms Regulate Gene Expression in Cancer Cells - News Center
Research on RNA and TOP1 can lead to new cancer therapies by targeting their interactions during DNA transcription.
Remodelling of the translatome controls diet and its impact on tumorigenesis - Nature
Fasting influences health through a new lipid-mediated signaling pathway that regulates translation and ketogenesis, with implications for cancer therapy.
Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers - Nature
WRN is identified as a synthetic lethal target in MSI cells due to its helicase function, offering potential for targeted cancer therapy.