Immune responses in checkpoint myocarditis across heart, blood and tumourThe study investigates immune responses in patients with immune-related myocarditis using advanced sequencing technologies.
Ultra-precise 3D maps of cancer cells unlock secrets of how tumours growDetailed maps of tumor cells are revealing insights into cancer biology and treatment options.
Mutant-selective AKT inhibition through lysine targeting and neo-zinc chelation - NatureAKT1 E17K mutation poses a challenge for treatment; targeted inhibitors offer a promising solution without the side effect of hyperglycaemia.
Ultra-precise 3D maps of cancer cells unlock secrets of how tumours growDetailed maps of tumor cells are revealing insights into cancer biology and treatment options.
Mutant-selective AKT inhibition through lysine targeting and neo-zinc chelation - NatureAKT1 E17K mutation poses a challenge for treatment; targeted inhibitors offer a promising solution without the side effect of hyperglycaemia.
Uncovering Regulatory Mechanisms of T-cells in Chronic Inflammation - News CenterLag3 expression in regulatory T-cells is critical for preventing autoimmune inflammation and may be a target for therapies in inflammatory conditions and cancer.
Transferrin receptor targeting chimeras for membrane protein degradation - NatureTransTACs represent a promising strategy for targeted cancer therapy through the degradation of membrane proteins.
Intercellular Mechanisms Regulate Gene Expression in Cancer Cells - News CenterResearch on RNA and TOP1 can lead to new cancer therapies by targeting their interactions during DNA transcription.
Remodelling of the translatome controls diet and its impact on tumorigenesis - NatureFasting influences health through a new lipid-mediated signaling pathway that regulates translation and ketogenesis, with implications for cancer therapy.
Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers - NatureWRN is identified as a synthetic lethal target in MSI cells due to its helicase function, offering potential for targeted cancer therapy.