"I think that the default way people are going to choose to have kids is via IVF and embryo screening,"
"There's just a massive amount of risk that you can take off of the table."
"these monogenic diseases can be just completely avoided,"
"you can now mitigate the genetic component of that risk by these double-digit numbers. You're talking about in the worst case 30 percent and in the best case up to 80 percent."
Orchid offers whole-genome screening of embryos for IVF, analyzing embryo DNA before implantation to lower the risk of genetically influenced conditions. Embryo screening can prevent monogenic diseases that affect an estimated 4 percent of people worldwide. Many chronic diseases have genetic components, and analyzing multiple embryos can reduce that genetic risk by double-digit percentages. For example, analyzing five embryos can mitigate genetic contributions to some chronic diseases by roughly 30 percent up to 80 percent, depending on disease prevalence, number of embryos analyzed, and effect sizes of screened genetic variants. George Church is an investor and regards the screening as highly cost-effective.
Read at WIRED
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