"AICAR peptide (5‑aminoimidazole‑4‑carboxamide ribonucleotide, also known as ZMP) is a naturally occurring purine biosynthesis intermediate that mimics adenosine monophosphate (AMP). Research suggests that this peptide may act as a cell-permeable analog of AMP, activating AMP-activated protein kinase (AMPK) and thereby supporting cellular energy regulation in various research models. It is of keen interest for its broad metabolic and signaling properties, and the benefits these properties may present to ongoing research."
"The AICAR peptide may mimic AMP and thus may activate AMPK in research models. AMPK is understood to act as an energy sensor kinase that modulates pathways governing glucose uptake, fatty acid oxidation, and mitochondrial biogenesis. When AMPK is stimulated, pathways such as insulin‑responsive glucose transporter translocation (GLUT4 mobilization), inhibition of acetyl‑CoA carboxylase (ACC), and suppression of lipid synthesis are often engaged."
"Investigations suggest that AICAR peptide may exert support even in the absence of robust AMPK activation. Some research suggests that glucose uptake improvements may occur independently of AMPK in certain contexts, possibly implicating ancillary pathways, such as ERK1/2 phosphorylation or alternative kinase cascades. These findings suggest a complex mechanism whereby AICAR peptide may support metabolism through complementary or parallel signaling pathways."
AICAR peptide, a purine biosynthesis intermediate also known as ZMP, can enter cells and mimic AMP, activating AMP‑activated protein kinase (AMPK). AMPK activation promotes GLUT4 translocation, increases glucose uptake, inhibits acetyl‑CoA carboxylase to suppress lipid synthesis, enhances fatty‑acid oxidation, and stimulates mitochondrial biogenesis. AICAR may also improve glucose uptake via AMPK‑independent mechanisms, potentially involving ERK1/2 phosphorylation or alternative kinase cascades. AICAR may regulate insulin receptor signaling in skeletal muscle models. These combined actions position AICAR as a multifaceted modulator of cellular energy and metabolic pathways.
Read at stupidDOPE | Est. 2008
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