Human cytomegalovirus (HCMV) infects a large portion of the population and can cause congenital birth defects and multiple organ problems. HCMV infection remodels the infected cell over a 5–10 day replication cycle. Chromatin conformation capture (Hi-C) and nascent transcriptomics reveal widespread disorganization of chromatin interactions and failure of compartment formation. The virus induces abnormal host gene expression and creates a novel microtubule-organizing center that rotates the nucleus. Nuclear rotation spatially separates host chromatin from viral DNA replication centers. These changes help explain how HCMV manipulates host genome architecture during infection.
Human cytomegalovirus is a widespread virus associated with congenital birth defects and several other serious conditions,
It also has a very unusual replication cycle that spans 5 to 10 days, during which it extensively remodels the cell.
In previous research, we found that the virus does this to spatially separate host chromatin from viral DNA replication centers,
But we still didn't know what was happening at a genetic level.
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