"Rete ridges are a hard-to-study feature of the skin that could harbour the stem cells needed to allow it to regenerate. There aren't many animal models available to study them in detail, so these researchers scoured the animal kingdom to find the skin that most resembled humans'. Now they've found clues as to how these ridges form, which they hope could one day enable us to reverse ageing in skin."
Rete ridges are undulating structures at the epidermal–dermal interface that may house stem cells crucial for skin regeneration. Limited animal models have hindered detailed study, so researchers surveyed diverse species to find skin most analogous to human skin. Comparative analysis revealed morphological and developmental clues about how rete ridges form. Insights into ridge formation and resident stem-cell niches could inform strategies to stimulate regeneration and potentially reverse aspects of skin ageing through targeted biomedical approaches.
Read at Nature
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