"Lipid transfer proteins (LTPs) maintain the specialized lipid compositions of organellar membranes1,2. In humans, many LTPs are implicated in diseases3, but for the majority, the cargo and auxiliary lipids facilitating transfer remain unknown. We have combined biochemical, lipidomic and computational methods to systematically characterize LTP-lipid complexes4 and measure how LTP gains of function affect cellular lipidomes. We identified bound lipids for approximately half of the hundred LTPs analyzed, confirming known ligands, while discovering new ones across most LTP families."
"Lipid transfer proteins (LTPs) maintain the specialized lipid compositions of organellar membranes1,2. In humans, many LTPs are implicated in diseases3, but for the majority, the cargo and auxiliary lipids facilitating transfer remain unknown. We have combined biochemical, lipidomic and computational methods to systematically characterize LTP-lipid complexes4 and measure how LTP gains of function affect cellular lipidomes. We identified bound lipids for approximately half of the hundred LTPs analyzed, confirming known ligands, while discovering new ones across most LTP families. Gains in LTP function affected the"
Lipid transfer proteins maintain specialized lipid compositions of organellar membranes. Many human LTPs are implicated in disease, yet for most the cargo and auxiliary lipids that facilitate transfer remain unknown. Biochemical, lipidomic and computational methods were combined to systematically characterize LTP-lipid complexes and to measure how LTP gains of function alter cellular lipidomes. Bound lipids were identified for approximately half of about one hundred LTPs analyzed, confirming known ligands and revealing new ligands across most LTP families. Gains in LTP function produced measurable changes in cellular lipidomes, indicating widespread functional impacts of LTP cargo diversity.
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