"A new study from researchers in Germany found that caffeine from coffee and other sources can reduce the effectiveness of certain antibiotics against harmful bacteria. Scientists at the Universities of Tübingen and Würzburg discovered that caffeine triggers a complex chain reaction in E. coli bacteria that makes them less susceptible to antibiotics like ciprofloxacin, a commonly prescribed fluoroquinolone used to treat urinary tract infections, pneumonia and many other bacterial infections."
""Caffeine triggers a cascade of events starting with the gene regulator Rob and culminating in the change of several transport proteins in E. coli - which in turn leads to a reduced uptake of antibiotics," University of Tübingen professor Ana Rita Brochado said in an announcement of the study's publication. The researchers describe this phenomenon as an "antagonistic interaction" between caffeine and certain antibiotics."
Caffeine from coffee and other sources can reduce the susceptibility of E. coli to certain antibiotics by triggering a regulatory cascade that begins with the gene regulator Rob and alters multiple transport proteins, lowering antibiotic uptake. The change reduces effectiveness of fluoroquinolones such as ciprofloxacin, commonly used for urinary tract infections, pneumonia and other bacterial infections. The interaction is described as antagonistic because caffeine-driven regulation diminishes antibiotic entry rather than relying on classic resistance genes. Ninety-four substances including antibiotics, prescription drugs and common food ingredients were found to influence bacterial gene expression and transport protein behavior, producing subtle, low-level resistance shifts.
Read at Daily Coffee News by Roast Magazine
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