"Thetis cells (TCs) are a recently identified lineage of RORt+ antigen-presenting cells comprising four subsets including a tolerogenic subset, TC IV, that instructs tolerance to gut microbiota and food antigens16. A developmental wave of TCs during early life creates a critical window of opportunity for establishing intestinal tolerance1,5. Yet the ontogeny of TCs and the cues shaping their abundance and heterogeneity remain unknown, limiting efforts to harness their therapeutic potential."
"Here we identify a population of RORt+ progenitors, termed Thetis-Lymphoid Tissue inducer progenitors (TLP), that give rise to the immediate TC progenitor (TCP) and the Lymphoid Tissue inducer progenitor (LTiP), and identify PU.1 as the transcription factor governing TC fate. Despite transcriptional similarity to myeloid-derived conventional dendritic cells (cDCs), we show that TCs descend from the common lymphoid progenitor (CLP)."
Thetis cells (TCs) are RORt+ antigen-presenting cells comprising four subsets, including tolerogenic TC IV that enforces tolerance to gut microbiota and food antigens. A developmental wave of TCs during early life creates a critical window for establishing intestinal tolerance. A population of RORt+ progenitors, termed Thetis-Lymphoid Tissue inducer progenitors (TLP), gives rise to immediate TC progenitors (TCP) and LTi progenitors (LTiP). PU.1 functions as the transcription factor governing TC fate. Despite transcriptional similarity to myeloid-derived conventional dendritic cells, TCs originate from the common lymphoid progenitor lineage.
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