Cats may hold clues for human cancer treatment

"The first detailed genetic map of cancer in pet cats reveals striking similarities with human versions of the disease, possibly helping find new ways to treat cancers in both. Scientists analysed tumour DNA from almost 500 domestic cats, uncovering key genetic mutations linked with the condition. Cancer is one of the main causes of illness and death in cats, however, very little is known about how it develops."

"They found many of the genes driving cat cancers are mirrored in humans, suggesting the two species share key biological processes that allow tumours to grow and spread. The scientists say the household cat could hold the key to understanding certain types of breast cancer, such as triple negative breast cancer. Around 15 out of 100 breast cancers are of this type."

Scientists analysed tumour DNA from almost 500 domestic cats and identified key genetic mutations associated with feline cancers. Many genes that drive cat tumours are mirrored in human cancers, indicating shared biological processes that enable tumour growth and spread. Domestic cats develop triple-negative-like breast cancer more frequently than humans, providing access to samples relevant to that aggressive subtype and potential clues for novel therapies. Cats and dogs share living environments with humans, exposing them to similar environmental risk factors that could illuminate cancer causes and prevention. Improved genetic knowledge of feline cancer could inform treatments and prevention strategies for both cats and people.

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