"The review from the British Medical Journal looked at nine of the top studies, which found a correlation between use of the over-the-counter pain medication while pregnant and child neurodevelopment. The review included the study touted by officials within the Trump administration to back up their repeated warnings to pregnant women not to take acetaminophen. BMJ found that the studies contained critical flaws and were of very low quality."
"Some of the issues with the previous studies include having no comprehensive search of the scientific literature, not listing excluded studies or why they were excluded, inaccurate study designs, and the use of non-standard tools for bias risk assessments. Dr. Shakila Thangaratinam, co-author of the review and executive dean of the Institute of Life Course and Medical Sciences at the University of Liverpool, told ABC News that the news study comes in part because of the new scrutiny on the topic brought about by President Donald Trump."
Nine influential studies that reported a correlation between prenatal acetaminophen (paracetamol) use and child neurodevelopmental outcomes contain critical methodological flaws and are of very low quality. Major issues include lack of comprehensive literature searches, failure to list or justify excluded studies, inaccurate study designs, and use of non-standard bias assessment tools. Existing evidence does not clearly link maternal paracetamol use during pregnancy with autism or ADHD in offspring. High-profile public warnings and media attention intensified scrutiny. Claims based on the flawed studies should not be treated as conclusive evidence of a causal relationship.
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