Marsupials, having split from eutherians 160 million years ago, exhibit different embryological processes, particularly concerning DNA methylation and X chromosome inactivation. Their unique patterns reveal that their placenta forms later and that pups are born in a less developed state. While eutherians demonstrate random XCI, marsupials exhibit imprinted XCI, silencing always the paternal X. Investigating preimplantation marsupial embryos can shed light on the role of DNA methylation in early mammalian development, presenting an alternative research model to further understand embryogenesis.
Marsupials, diverging from eutherians 160 million years ago, provide insights into mammalian embryology with unique early development processes influenced by DNA methylation.
Unlike eutherians, marsupials demonstrate a distinct X chromosome inactivation pattern; their paternal X is imprinted for silencing, contrasting with eutherian random XCI.
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