New England Patriots @ Buffalo Bills: Preview, prediction and odds
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New England Patriots @ Buffalo Bills: Preview, prediction and odds
"The New England Patriots travel to Buffalo this weekend for a Sunday Night Football showdown with the unbeaten Bills. After edging the Miami Dolphins 33-27 in Week 2, the Patriots have the chance to open 2-0 in AFC East play for the first time since 2019. The game also carries some extra history, as it will be New England's final regular-season appearance at Highmark Stadium before Buffalo moves into its new venue next year."
"The rivalry itself is one of the oldest in the AFC East, dating back to 1960. The Patriots hold a 79-51-1 advantage all-time, including a 37-26-1 record in Buffalo. They've also thrived in prime-time matchups against the Bills, going 9-2 overall and a perfect 4-0 on Sunday Night Football. Last season the sides split their meetings, with Buffalo taking a 24-21 win in December before New England responded two weeks later with a 23-16 victory to close out the year."
"Statistically, Buffalo has looked dominant in 2025, boasting the league's second-ranked offense at 404 yards per game and averaging 33.3 points per outing. The Patriots, meanwhile, sit at 2-2 but rank in the top ten in scoring at 25.5 points per game and have the NFL's second-best rush defense, allowing just 77.5 yards on the ground per contest. Sunday's clash will pit that defense against the Bills' league-leading rushing attack, which averages 163.5 yards."
New England visits Buffalo on Sunday Night aiming to hand the unbeaten Bills their first loss and to open 2-0 in AFC East play for the first time since 2019. The game is Buffalo's final regular-season contest at Highmark Stadium before the franchise moves to a new venue. The Patriots begin a challenging three-game road stretch that includes New Orleans and Tennessee. The rivalry dates to 1960, with New England holding the all-time edge and a strong prime-time record versus Buffalo. Buffalo's offense ranks second in yards and scoring while New England counters with a top-10 offense and the NFL's second-best rush defense. Several Patriots chase career milestones in rushing, receiving and kick returns.
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