Treatment-resistant depression (TRD) presents a significant public health challenge, greatly affecting individuals and healthcare systems yet often overlooked in clinical practice. Patients exhibit more severe symptoms and prolonged illness compared to those with treatment-responsive depression. This results in substantial personal and societal costs. A recent study involving 2,461 individuals with major depressive disorder highlighted the critical need for effective treatment and care coordination. Evidence from both quantitative and qualitative data underscores the urgency to recognize and address TRD in mental health policies and practices.
Many individuals with treatment-resistant depression experience persistent symptoms, leading them to shift from one failed treatment to another, often disengaging from care altogether.
Our research highlights the significant personal, social, and economic costs of TRD, affecting not only the individual but also straining healthcare systems significantly.
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