"Statistics show that about one-third of people with depression achieve remission-meaning their symptoms are gone-with traditional antidepressant medications. This matched my experience treating people, and I had grown to accept that this was as good as it gets. Although I wasn't thrilled with the fact that many people continued to struggle with significant symptoms of persistent depression, it seemed this was as good as we could do."
"A Study That Seemed Too Good to Be True While reading through studies describing novel treatments for depression, I stumbled upon an article written by a group of doctors from Brazil describing results that seemed too good to be true. Diogo Lara and his colleagues administered a very low dose of ketamine-just 10 mg under the tongue (sublingual)-to 26 patients who suffered from treatment-refractory depression or bipolar disorder."
Traditional antidepressant medications produce remission in about one-third of depressed patients, with another third showing partial improvement and a final third not responding. A Brazilian study treated 26 patients with treatment-refractory depression or bipolar disorder using 10 mg sublingual ketamine and reported 77% improvement. Low-dose sublingual ketamine can be administered affordably at home and may provide more durable benefits than intravenous ketamine. A low-dose protocol pioneered by Dr. Rachel Wilkenson has been applied to hundreds of patients with remarkable outcomes. Low-dose sublingual ketamine offers a promising option for people who fail to remit on standard treatments.
Read at Psychology Today
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