"The speed and depth of the woman's response was remarkable and the therapy had significantly improved her quality of life. Clinical trials were needed to learn how durable the therapy was and whether it would be effective for other autoimmune diseases."
"The patient had no treatment options left and would not have left the ward as she needed daily transfusions. In addition to AIHA, the woman had two other autoimmune diseases."
"With no options left, the doctors offered a treatment known as CAR (chimeric antigen receptor) T-cell therapy, which has proved gamechanging."
A 47-year-old woman with three life-threatening autoimmune diseases underwent CAR T-cell therapy after nine ineffective treatments. Previously reliant on daily blood transfusions, she experienced a remarkable recovery within weeks. All three diseases showed improvement, leading to treatment-free remission for 14 months. The therapy reset her immune system, significantly enhancing her quality of life. Clinical trials are necessary to assess the therapy's durability and effectiveness for other autoimmune conditions. The woman suffered from autoimmune haemolytic anaemia, immune thrombocytopenia, and antiphospholipid syndrome, all linked to dysfunctional B-cells.
Read at www.theguardian.com
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