""Sometimes there are circuits that are overconnected, that are underconnected, there's different brain regions that are at play, there's different cell types. Our current set of interventions just don't have the precision we need. The vision of the program is, 'Can we build more precise neurotechnologies to interface at the circuit level?'""
""At WIRED Health, Carolan highlighted the potential of ultrasound technologies not only to modulate the brain, but to allow scientists to obtain new information about the brain's circuitry in a particular patient.""
""One ARIA-funded team at Imperial College London is working on a project combining ultrasound and gene therapy to try to image gene expression in real-time in neurons, potentially revolutionizing our understanding of brain disorders.""
The UK's Advanced Research and Innovation Agency (ARIA) was established in 2023 with over £1 billion in funding to pursue high-risk, high-reward projects. One key initiative focuses on developing tailored methods to modulate the human brain, targeting disorders like epilepsy and Alzheimer's. ARIA program director Jacques Carolan emphasizes the need for precision in interventions, as current methods lack effectiveness. The agency has funded 19 teams exploring various innovative approaches, including ultrasound technologies and deep brain stimulation, to better understand and treat brain circuitry disorders.
Read at WIRED
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