"Cats, along with dogs, are the animals that spend the most time with humans. They share spaces, routines, and even illnesses. They are exposed to almost all the same environmental stressors that induce tumors in people. However, unlike what happens with dogs, cancer research in felines is very limited. Now, a huge study published in Science, using hundreds of tumor samples, has obtained the most complete oncogenome of the domestic cat."
"Cancer is one of the leading causes of morbidity and mortality in older cats. However, very little is known about the genetics that drive these cancers, notes Louise van der Weyden, a researcher at the Wellcome Sanger Institute in the U.K. and senior author of a study that analyzed tumor samples (and adjacent healthy tissue) from 493 cats. It seemed deeply unfair to us that in this era of precision medicine, where targeted therapies are the treatment of choice for cancer in humans,"
Domestic cats share living environments and many environmental stressors with humans, exposing them to similar tumor-inducing factors. Cancer is a leading cause of illness and death in older cats, yet the genetic drivers of feline cancers have been poorly characterized. A collaborative team analyzed tumor and adjacent healthy tissue from 493 cats and sequenced 978 genes linked to feline tumors, corresponding to roughly 1,000 human cancer-related genes. Samples covered 13 major tumor types, including osteosarcoma, pancreatic adenocarcinoma, and various mammary carcinomas, sourced from biopsies and necropsies of mostly mixed-breed domestic cats.
Read at english.elpais.com
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