"We are providing an unedited version of this manuscript to give early access to its findings. Before final publication, the manuscript will undergo further editing. Please note there may be errors present which affect the content, and all legal disclaimers apply."
"HIV cure is exceptionally rare, documented in only six cases among the estimated 88 million individuals who have acquired HIV since the epidemic's onset16. Successful cures, including the pioneering Berlin patient, are limited to individuals receiving allogeneic stem cell transplants (allo"
"Sustained HIV-1 remission after heterozygous CCR532 stem cell transplantation"
Sustained HIV-1 remission occurred after allogeneic stem cell transplantation using donor cells heterozygous for the CCR5Δ32 allele. HIV cure occurrences are exceptionally rare, with only six documented cases among an estimated 88 million people infected since the epidemic began. Previously reported successful cures, including the Berlin patient, were achieved after allogeneic stem cell transplantation. Allogeneic transplantation can, in rare instances, eradicate or durably control HIV-1 infection. The heterozygous CCR5Δ32 transplant outcome indicates that alternative donor genotypes may contribute to long-term remission when combined with transplant-associated factors.
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