A spatial transcriptomics atlas was developed to improve understanding of niche cellular interactions in the gastrointestinal tract linked to inflammatory bowel diseases. Inflammatory bowel diseases include Crohn’s disease and ulcerative colitis and cause chronic digestive tract inflammation. Cellular signaling and cell-to-cell interactions in the intestinal microenvironment influence inflammation, and single-cell transcriptomic signatures can associate with disease development, progression, and treatment responsiveness. Existing approaches lack spatial context needed to analyze how cells are organized and interact within gastrointestinal tissue. Spatial omics creates a need to determine how to use the technology effectively, select ideal platforms, and assess feasibility for implementation across large clinical trial programs and consortiums to enable a unified reverse translational approach.
"A novel spatial transcriptomics atlas developed by Northwestern Medicine scientists may improve the understanding of niche cellular interactions in the gastrointestinal tract that promote the development of inflammatory bowel diseases, as detailed in a recent study published in Nature Communications."
"Cellular signaling and cell-to-cell interactions in the intestinal microenvironment have been known to drive or reduce inflammation in IBD, and previous work has shown that characterizing single-cell transcriptomic signature data can help in identifying associations with IBD development, progression and treatment responsiveness."
"Unfortunately, these methods currently lack the spatial context to properly analyze the organization and interactions of cells within gastrointestinal tissue, which can help reveal new biomarkers and inform future drug development, according to Dulai."
""With the growth in spatial omics, there was a tremendous need in the space for us to understand what is the best way to use the technology, which platform would be ideal to give us the most information possible, and is it feasible to start implementing this across large clinical trial programs or large consortiums so that we can start working towards a unified approach for reverse translational sc""
#spatial-transcriptomics #inflammatory-bowel-disease #cell-cell-interactions #gastrointestinal-tract #biomarker-discovery
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