""I learned about this literally about three hours ago," Dr. Ramsdell said. "It's a humbling experience, to be sure...It's surreal, it's surprising.""
""Being able to take your own immune system at some level, reprogram it based on what we now know, to go reset itself so that you don't react to your own tissues," Dr. Ramsdell said."
""What these three folks did was to identify both the cell and a gene that's turned on in those cells, which really gives these cells the superpower to go around as sentinels and shut it down," immunologist and diabetes expert Mark Anderson said. "The idea would be we could use these cells in this gene to go in and shut down just that part, the unwanted autoimmune response, but leave all the good parts of the immune system behind.""
Dr. Fred Ramsdell and colleagues Mary Brunkow and Shimon Sakaguchi received the 2025 Nobel Prize in Medicine for discoveries about immune regulation. Ramsdell learned of the award after returning from a camping trip and works with Sonoma Biotherapeutics. The prize recognizes identification of a specific immune cell and a gene that gives those cells the ability to act as sentinels and shut down autoimmune reactions. The findings are critical to understanding Type 1 Diabetes, Rheumatoid Arthritis and Lupus. The discoveries open possibilities to reprogram the immune system to stop self-directed attacks while preserving protective immunity, offering hope for future patient therapies.
Read at ABC7 San Francisco
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