"Article Published: 13 November 2025 Robert A. Montgomery orcid.org/0000-0003-2728-45521 na1, Jeffrey M. Stern orcid.org/0000-0001-5588-03571 na1, Farshid Fathi orcid.org/0000-0002-0280-76122 na1, Nathan Suek2 na1, Jacqueline I. Kim orcid.org/0000-0001-8165-525X3, Karen Khalil1, Benjamin Vermette orcid.org/0000-0003-4292-12812, Vasishta S. Tatapudi1, Aprajita Mattoo2, Edward Y. Skolnik4,5, Ian S. Jaffe orcid.org/0000-0002-7309-308X3, Imad Aljabban1,2, Tal Eitan orcid.org/0000-0002-0811-68711, Shivani Bisen orcid.org/0000-0002-2585-01546, Elaina P. Weldon1, Valentin Goutaudier7, Erwan Morgand7, Fariza Mezine7, Alessia Giarraputo7, Idris Boudhabhay8, Patrick Bruneval orcid.org/0000-0002-2350-29147, Aurelie Sannier7, Kevin Breen2,9,"
"Yasmeen S. Saad orcid.org/0000-0001-6612-79852, Constanza Bay Muntnich2, Simon H. Williams1,10, Weimin Zhang orcid.org/0000-0002-8836-143810, Larisa Kagermazova orcid.org/0009-0004-7494-284X10, Eloi Schmauch11, Chandra Goparaju12, Rebecca Dieter1, Nikki Lawson1, Amy Dandro13, Ana Laura Fazio-Kroll13, Lars Burdorf13, David Ayares13, Marc Lorber14, Dorry Segev3,15, Nicole Ali1, David S. Goldfarb orcid.org/0000-0002-9215-12734,16, Victoria Costa17, Timothy Hilbert17, Sapna A. Mehta1, Ramin S. Herati orcid.org/0000-0003-2613-40504, Harvey I. Pass12, Ming Wu17, Jef D. Boeke orcid.org/0000-0001-5322-494618,19,"
Multidisciplinary research efforts address xenotransplantation and transplant immunology within preclinical and translational frameworks. The work concentrates on bridging preclinical models and translational strategies to improve cross-species graft compatibility and immune management. Genetic, immunological, surgical, and regulatory dimensions are integrated to reduce rejection risk and enhance graft survival. Collaborative approaches combine expertise across biology, medicine, genomics, and bioethics to inform safe implementation pathways. Emphasis is placed on experimental outcomes that can guide translational decision-making, biosafety considerations, and potential clinical translation while acknowledging the need for rigorous validation and regulatory oversight.
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