People who stop using Mounjaro tend to regain weight and lose other health benefits, says study

"People who stop using the weight-loss jab Mounjaro not only tend to regain weight, but experience a reversal in other health improvements too, research suggests. Mounjaro, which contains the active ingredient tirzepatide, has become a popular medication for weight loss, with studies suggesting that it can help people lose an average of 20% of their body weight after 72 weeks of treatment."

"Naveed Sattar, a professor of cardiometabolic medicine at the University of Glasgow who was not part of the team but was involved with previous work on the trial, said the findings are not a surprise, as excess weight is a well-established driver of elevated blood pressure and impaired glucose control. Consequently, when weight lost through therapeutic interventions is regained, these cardiometabolic risk factors typically rise in proportion to the speed and extent of weight regain, he said."

Mounjaro contains the active ingredient tirzepatide and can produce average weight loss of about 20% of body weight after 72 weeks of treatment. Stopping tirzepatide commonly results in much of the lost weight being regained and causes reversal of other health improvements, including reductions in blood pressure and levels of bad cholesterol. Excess weight is a well-established driver of elevated blood pressure and impaired glucose control, so regained weight drives cardiometabolic risk factors back up in proportion to the speed and extent of regain. Sustained weight management remains a critical challenge, and stopping these drugs may remove cardiovascular protective effects.

Read at www.theguardian.com