New weight-loss shot appears to outperform other obesity drugs on market

Retatrutide, a once-weekly triple hormone receptor agonist, produced substantial weight loss in a large phase three trial. Adults with obesity or overweight and at least one weight-related comorbidity, without diabetes, were randomized to receive retatrutide at 4mg, 9mg, or 12mg or placebo. Over 80 weeks, the 9mg and 12mg groups lost an average of 64.4 lbs (25.9%) and 70.3 lbs (28.3%), respectively. The 4mg group lost an average of 47.2 lbs (19.0%). About 45.3% of participants on the 12mg regimen achieved at least 30% weight loss. BMI reductions were also notable, with 65.3% dropping below 30, including 37.5% of those starting at BMI 40 or higher.

"retatrutide, a once-weekly triple hormone receptor agonist, led to an average weight loss of 70.3lbs (28.3%) over 80 weeks among participants receiving the 12mg dose, with 45.3% achieving at least 30% weight loss. In Eli Lilly's phase three trial, 2,339 adults who have obesity or are overweight, have at least one weight-related comorbidity, and have no diabetes were randomized to receive retatrutide in doses of 4mg, 9mg, 12mg, or a placebo."

"Over 80 weeks, participants receiving the highest doses achieved substantial weight loss, the company said. Patients taking 9mg and 12mg of retatrutide lost an average of 64.4lbs (25.9%) and 70.3lbs (28.3%), respectively. Meanwhile, patients on the 4mg dose lost 47.2lbs (19.0%) despite only a single dose-escalation step."

"The company also reported that 65.3% of participants on the 12mg regimen reduced their BMI below 30 the clinical cutoff for obesity including 37.5% of individuals who began the trial with a BMI of 40 or higher. Based on Eli Lilly's trial, weight loss with retatrutide appears to exceed what has been typically possible with other weight-loss medications, including Eli Lilly's own Zepbound and Novo Nordisk's Wegovy."

"On Zepbound, users can expect to lose an average of 15% to 20% of starting body weight over 72 weeks. On Wegovy, users can expect to lose an average of 14% to 19% of starting body weight gradually over 64 to 72 weeks."

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