"Replication-competent virus and HIV-specific T cell responses were absent, and HIV antibody responses showed a gradual decline. The absence of HIV-specific T cell responses in our data supports the hypothesis that such an absence correlates with sustained HIV remission."
"A sibling has a 25 per cent probability of being a match for a transplant, and the frequency of CCR5Δ32/Δ32 is around one per cent in northern European populations."
A 64-year-old man in Oslo has likely been cured of HIV after five years in remission following a stem-cell transplant from his brother, who has a rare CCR5Δ32/Δ32 mutation. The transplant was performed to treat the man's bone marrow cancer. Two years post-transplant, tests showed no HIV DNA in his blood or gut, and no virus capable of multiplying. However, clinicians caution that this outcome is not a feasible cure for the general population due to the rarity of the mutation and the risks associated with stem-cell transplants.
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