"They had less risk of developing substance use disorders across several addictive substances, including opioids, cocaine, nicotine, alcohol, cannabis and other substances. The risk was about 15- to 20% lower for most of these substances."
"Being on a GLP-1 reduced the risk of drug-related death, drug overdose, drug-related hospitalization and suicidal attempts."
"GLP-1 drugs seem to work by reducing the hormone dopamine in what's known as the brain's mesolimbic system. That is the center of the brain that is responsible for reward-signaling - motivation."
A large Veterans Affairs study analyzing over 600,000 people with Type 2 diabetes over three years found that those taking GLP-1 drugs experienced significantly lower risks of developing substance use disorders. The reduction applied across multiple addictive substances including opioids, cocaine, nicotine, alcohol, and cannabis. For individuals with addiction histories, GLP-1 use reduced risks of drug-related death, overdose, hospitalization, and suicide attempts. The benefits appeared consistent across demographic groups including women and younger men. GLP-1 drugs appear to work by reducing dopamine in the brain's mesolimbic system, which controls reward signaling and motivation.
Read at www.npr.org
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