German researchers find highly effective HIV antibody DW 10/15/2025
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German researchers find highly effective HIV antibody  DW  10/15/2025
"They were all infected with HIV, but had developed a particularly strong and broadly effective antibody response against the virus, on their own without any medical intervention. The researchers tested more than 800 different antibodies from these blood samples for their ability to neutralize HIV. One of them, named 04_A06, stood out. The antibody blocks a site where the virus binds to cells when it infects a person."
"Antibodies in the human immune system are produced by B lymphocytes, or B cells. When B cells detect pathogens, they become plasma cells that release antibodies, such as the 04_A06 antibody discovered by the Cologne researchers. The researchers decoded this process, or "blueprint," for the 04_A06 antibody in the hope that they could reproduced it. "You use the genetic blueprint of the antibody, transfer it to a cell line in the laboratory and use another cell and tell it: Please produce this antibody,""
Worldwide HIV/AIDS has caused about 44 million deaths since the early 1980s, with roughly 630,000 AIDS-related deaths reported in 2024. Researchers examined blood from 32 people who developed unusually strong, broadly neutralizing antibody responses without medical intervention. Over 800 antibodies were tested for neutralizing activity, and one, designated 04_A06, blocked the viral binding site and prevented HIV from entering cells. Antibodies originate from B lymphocytes that differentiate into plasma cells to release antibodies. The genetic "blueprint" of 04_A06 was decoded so that the antibody sequence can be transferred into cell lines to produce the antibody in the laboratory.
Read at www.dw.com
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