"We are providing an unedited version of this manuscript to give early access to its findings. Before final publication, the manuscript will undergo further editing. Please note there may be errors present which affect the content, and all legal disclaimers apply. DNA vaccines HIV infections Immunological memory Translational immunology The identification of therapeutic strategies to induce sustained antiretroviral therapy (ART)-free control of HIV infection is a major priority.1 Combination immunotherapy including HIV vaccination, immune stimulation/latency reversal, and passive tr"
"Correlates of HIV-1 control after combination immunotherapy Article Published: 01 December 2025 M. J. Peluso orcid.org/0000-0003-0585-62301 na1, D. A. Sandel orcid.org/0000-0002-4095-20361,2,3 na1, A. N. Deitchman orcid.org/0000-0002-4722-463X4 na1, S. J. Kim1,5, T. Dalhuisen orcid.org/0000-0001-9132-04961, H. P. Tummala orcid.org/0009-0005-9493-34974, R. Tiburcio1, L. Zemelko1, G. M. Borgo1, S. S. Singh1, K. Schwartz1, M. Deswal1, M. C. Williams1, R. Hoh1, M. Shimoda orcid.org/0000-0002-6627-46241, S. Narpala6, L. Serebryannyy6, M. Khalili orcid.org/0000-0001-9178-91391,"
Therapeutic strategies aim to induce sustained antiretroviral therapy (ART)-free control of HIV infection. Combination immunotherapy integrates HIV vaccination, immune stimulation/latency reversal, and passive immunotherapy to target viral reservoirs and enhance antiviral immune responses. DNA vaccines and induction of durable immunological memory are central components of this approach. Correlate analyses identify immunological features associated with post-treatment HIV-1 control following combination immunotherapy. Translational immunology connects mechanistic insights with clinical interventions to refine strategies for durable, ART-free remission and to prioritize targets for future therapeutic development.
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