"Interventions to induce lasting HIV remission are needed to obviate the requirement for lifelong antiretroviral therapy (ART). Durable post-intervention control (PIC) of viremia has been achieved in a subset of individuals following broadly neutralizing anti-HIV-1 antibody (bNAb) administration and analytical treatment interruption (ATI)1-4. Prior studies support a role for CD8+ T cells5-9 but the precise features of CD8+ T cells involved in PIC remain unclear."
"Here we mapped and functionally profiled CD8+ T cell responses to autologous HIV epitopes using longitudinal samples from four ATI trials in bNAb recipients. PIC was associated with superior pre-intervention HIV-specific CD8+ T cell proliferative capacity, stem cell-like memory phenotype, and recall cytotoxicity against autologous HIV peptide-pulsed CD4+ T cells. CD8+ T cell stemness was further increased following bNAb administrati"
Interventions that combine broadly neutralizing anti-HIV-1 antibodies (bNAbs) with analytical treatment interruption (ATI) can lead to durable post-intervention control (PIC) of viremia in a subset of individuals. Longitudinal mapping and functional profiling of CD8+ T cell responses to autologous HIV epitopes across four ATI trials revealed that PIC associates with higher pre-intervention HIV-specific CD8+ T cell proliferative capacity, a stem cell-like memory phenotype, and stronger recall cytotoxicity against autologous HIV peptide-pulsed CD4+ T cells. Administration of bNAbs further increased CD8+ T cell stemness, linking enhanced CD8+ qualities to successful viral control after intervention.
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